Gene information
Official symbol NPPA
Official full name natriuretic peptide A
Gene type protein-coding gene
Chromosome1p36.22
Previous symbolANP; PND
Gene familyNeuropeptides
Resources
Entrez Gene 4878
HGNC HGNC:7939
Ensembl ENSG00000175206
Vega OTTHUMG00000002388
UCSC uc001ati.4
GO terms: 142 records
GO Description Category LogP Number of genes Detail
GO:0001664 G protein-coupled receptor binding GO Molecular Functions -22.7408810 35 More
GO:0001933 negative regulation of protein phosphorylation GO Biological Processes -19.8214973 59 More
GO:0002027 regulation of heart rate GO Biological Processes -9.97103962 23 More
GO:0003012 muscle system process GO Biological Processes -27.3938503 63 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003018 vascular process in circulatory system GO Biological Processes -47.1670528 52 More
GO:0003073 regulation of systemic arterial blood pressure GO Biological Processes -22.2238525 34 More
GO:0003085 negative regulation of systemic arterial blood pressure GO Biological Processes -9.78130162 11 More
GO:0003161 cardiac conduction system development GO Biological Processes -7.69659659 12 More
GO:0003170 heart valve development GO Biological Processes -11.9253160 20 More
GO:0003176 aortic valve development GO Biological Processes -8.77845673 13 More
GO:0003179 heart valve morphogenesis GO Biological Processes -9.26383069 16 More
GO:0003180 aortic valve morphogenesis GO Biological Processes -6.3383802 10 More
GO:0003299 muscle hypertrophy in response to stress GO Biological Processes -3.72261873 5 More
GO:0003300 cardiac muscle hypertrophy GO Biological Processes -10.9367469 14 More
GO:0005179 hormone activity GO Molecular Functions -33.3562443 33 More
GO:0005184 neuropeptide hormone activity GO Molecular Functions -7.01061583 7 More
GO:0006163 purine nucleotide metabolic process GO Biological Processes -1.90037391 10 More
GO:0006164 purine nucleotide biosynthetic process GO Biological Processes -1.46962935 6 More
GO:0006457 protein folding GO Biological Processes -2.73896005 9 More
GO:0006469 negative regulation of protein kinase activity GO Biological Processes -12.6852914 37 More
GO:0006753 nucleoside phosphate metabolic process GO Biological Processes -1.97459133 12 More
GO:0006814 sodium ion transport GO Biological Processes -1.68216350 6 More
GO:0006937 regulation of muscle contraction GO Biological Processes -20.8046481 43 More
GO:0006942 regulation of striated muscle contraction GO Biological Processes -11.0877013 23 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007218 neuropeptide signaling pathway GO Biological Processes -4.86030435 9 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0007565 female pregnancy GO Biological Processes -18.4002911 25 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008016 regulation of heart contraction GO Biological Processes -27.6827716 55 More
GO:0008217 regulation of blood pressure GO Biological Processes -35.2019435 60 More
GO:0009117 nucleotide metabolic process GO Biological Processes -2.02959005 12 More
GO:0009150 purine ribonucleotide metabolic process GO Biological Processes -1.73087600 10 More
GO:0009152 purine ribonucleotide biosynthetic process GO Biological Processes -1.36740531 6 More
GO:0009165 nucleotide biosynthetic process GO Biological Processes -1.85527211 8 More
GO:0009187 cyclic nucleotide metabolic process GO Biological Processes -4.57029927 9 More
GO:0009259 ribonucleotide metabolic process GO Biological Processes -1.59291266 10 More
GO:0009612 response to mechanical stimulus GO Biological Processes -18.7627330 44 More
GO:0010460 positive regulation of heart rate GO Biological Processes -6.02792411 9 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0014706 striated muscle tissue development GO Biological Processes -21.0654252 44 More
GO:0014887 cardiac muscle adaptation GO Biological Processes -3.72261873 5 More
GO:0014888 striated muscle adaptation GO Biological Processes -4.98581398 8 More
GO:0014896 muscle hypertrophy GO Biological Processes -12.7837947 16 More
GO:0014897 striated muscle hypertrophy GO Biological Processes -10.7141263 14 More
GO:0014898 cardiac muscle hypertrophy in response to stress GO Biological Processes -3.72261873 5 More
GO:0019693 ribose phosphate metabolic process GO Biological Processes -1.52492811 10 More
GO:0019932 second-messenger-mediated signaling GO Biological Processes -19.1717114 46 More
GO:0019934 cGMP-mediated signaling GO Biological Processes -6.05074470 6 More
GO:0019935 cyclic-nucleotide-mediated signaling GO Biological Processes -6.37341307 8 More
GO:0022898 regulation of transmembrane transporter activity GO Biological Processes -11.1988499 41 More
GO:0030001 metal ion transport GO Biological Processes -7.54203733 26 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031400 negative regulation of protein modification process GO Biological Processes -17.0986645 70 More
GO:0032409 regulation of transporter activity GO Biological Processes -16.9480646 53 More
GO:0032411 positive regulation of transporter activity GO Biological Processes -5.68668981 10 More
GO:0032412 regulation of ion transmembrane transporter activity GO Biological Processes -9.90560995 38 More
GO:0032414 positive regulation of ion transmembrane transporter activity GO Biological Processes -4.25838891 8 More
GO:0032872 regulation of stress-activated MAPK cascade GO Biological Processes -11.6818048 20 More
GO:0032873 negative regulation of stress-activated MAPK cascade GO Biological Processes -3.60984508 9 More
GO:0033673 negative regulation of kinase activity GO Biological Processes -12.5521161 39 More
GO:0034654 nucleobase-containing compound biosynthetic process GO Biological Processes -2.18989332 18 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0034767 positive regulation of ion transmembrane transport GO Biological Processes -11.2867591 18 More
GO:0035150 regulation of tube size GO Biological Processes -44.5138102 41 More
GO:0035296 regulation of tube diameter GO Biological Processes -44.6572858 41 More
GO:0035994 response to muscle stretch GO Biological Processes -4.25041921 7 More
GO:0042311 vasodilation GO Biological Processes -18.7593927 16 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0042391 regulation of membrane potential GO Biological Processes -15.0641346 59 More
GO:0043025 neuronal cell body GO Cellular Components -9.18558636 52 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043204 perikaryon GO Cellular Components -2.25381579 14 More
GO:0043266 regulation of potassium ion transport GO Biological Processes -7.37974754 20 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043270 positive regulation of ion transport GO Biological Processes -23.5832054 34 More
GO:0043405 regulation of MAP kinase activity GO Biological Processes -18.9267681 42 More
GO:0043407 negative regulation of MAP kinase activity GO Biological Processes -8.66647370 10 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043409 negative regulation of MAPK cascade GO Biological Processes -13.5471736 35 More
GO:0043500 muscle adaptation GO Biological Processes -8.52594673 12 More
GO:0043506 regulation of JUN kinase activity GO Biological Processes -3.13739094 5 More
GO:0043508 negative regulation of JUN kinase activity GO Biological Processes -3.41433421 5 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044297 cell body GO Cellular Components -11.7206640 62 More
GO:0044703 multi-organism reproductive process GO Biological Processes -20.5752550 28 More
GO:0044706 multi-multicellular organism process GO Biological Processes -20.0155761 28 More
GO:0045776 negative regulation of blood pressure GO Biological Processes -17.1357953 22 More
GO:0045823 positive regulation of heart contraction GO Biological Processes -10.6953794 15 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045933 positive regulation of muscle contraction GO Biological Processes -10.2635447 16 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0045989 positive regulation of striated muscle contraction GO Biological Processes -6.22004109 7 More
GO:0046328 regulation of JNK cascade GO Biological Processes -6.26985667 21 More
GO:0046329 negative regulation of JNK cascade GO Biological Processes -2.96833359 7 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048738 cardiac muscle tissue development GO Biological Processes -21.5979622 44 More
GO:0051348 negative regulation of transferase activity GO Biological Processes -13.2006110 43 More
GO:0051427 hormone receptor binding GO Molecular Functions -9.65736435 9 More
GO:0051924 regulation of calcium ion transport GO Biological Processes -18.2498286 49 More
GO:0055086 nucleobase-containing small molecule metabolic process GO Biological Processes -1.91021091 13 More
GO:0055117 regulation of cardiac muscle contraction GO Biological Processes -9.51337974 19 More
GO:0060306 regulation of membrane repolarization GO Biological Processes -5.46127869 10 More
GO:0060452 positive regulation of cardiac muscle contraction GO Biological Processes -7.34622031 5 More
GO:0060537 muscle tissue development GO Biological Processes -18.3336784 54 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070302 regulation of stress-activated protein kinase signaling cascade GO Biological Processes -11.5600448 20 More
GO:0070303 negative regulation of stress-activated protein kinase signaling cascade GO Biological Processes -3.60984508 9 More
GO:0071855 neuropeptide receptor binding GO Molecular Functions -7.75588867 8 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0071901 negative regulation of protein serine/threonine kinase activity GO Biological Processes -13.7044922 29 More
GO:0072521 purine-containing compound metabolic process GO Biological Processes -2.16218573 11 More
GO:0072522 purine-containing compound biosynthetic process GO Biological Processes -1.86520856 7 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0090066 regulation of anatomical structure size GO Biological Processes -32.7608623 52 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0090407 organophosphate biosynthetic process GO Biological Processes -3.52771570 18 More
GO:0097746 blood vessel diameter maintenance GO Biological Processes -44.6572858 41 More
GO:0098655 cation transmembrane transport GO Biological Processes -3.98966777 20 More
GO:0098660 inorganic ion transmembrane transport GO Biological Processes -4.47276690 21 More
GO:0098662 inorganic cation transmembrane transport GO Biological Processes -4.65654157 20 More
GO:0099623 regulation of cardiac muscle cell membrane repolarization GO Biological Processes -3.70345918 7 More
GO:0140115 export across plasma membrane GO Biological Processes -3.24021630 5 More
GO:0140352 export from cell GO Biological Processes -8.94733589 48 More
GO:1901293 nucleoside phosphate biosynthetic process GO Biological Processes -1.83737953 8 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1903169 regulation of calcium ion transmembrane transport GO Biological Processes -8.80532519 28 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1903524 positive regulation of blood circulation GO Biological Processes -11.6803256 16 More
GO:1904062 regulation of cation transmembrane transport GO Biological Processes -18.6629834 61 More
GO:1904064 positive regulation of cation transmembrane transport GO Biological Processes -10.8655330 17 More
GO:1905314 semi-lunar valve development GO Biological Processes -10.3278393 15 More
GO:2001257 regulation of cation channel activity GO Biological Processes -11.2578208 33 More
GO:2001259 positive regulation of cation channel activity GO Biological Processes -4.43623555 7 More
KEGG pathways: 10 records
KEGG Description Category LogP Number of genes Detail
hsa04022 cGMP-PKG signaling pathway KEGG Pathway -9.74555098 16 More
hsa04024 cAMP signaling pathway KEGG Pathway -7.78464854 30 More
hsa04066 HIF-1 signaling pathway KEGG Pathway -20.6790877 23 More
hsa04270 Vascular smooth muscle contraction KEGG Pathway -11.6218936 17 More
hsa04714 Thermogenesis KEGG Pathway -1.67288051 7 More
hsa04921 Oxytocin signaling pathway KEGG Pathway -1.98551660 6 More
hsa04923 Regulation of lipolysis in adipocytes KEGG Pathway -8.97402692 10 More
hsa04924 Renin secretion KEGG Pathway -9.25913478 11 More
hsa04925 Aldosterone synthesis and secretion KEGG Pathway -3.76850718 7 More
hsa05143 African trypanosomiasis KEGG Pathway -18.5080428 15 More
Drug-Gene interaction
view
Related drugs: 2 records
Drug name Interaction type Source PMID View
amlodipine PharmGKB 18212314 view
chlorthalidone PharmGKB 18212314 view
Related studies: 47 records
Molecular factor Omics type Application Objective MI type Reference
natriuretic peptides A proteomics adverse events[prognosis (bad)] acute myocardial infarction Nakamura M et al. Jpn Heart J. 1992
natriuretic peptides A proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Lissoni P et al. Eur J Med. 1992
natriuretic peptides A proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Gutierrez-Marcos FM et al. Eur Heart J. 1991
natriuretic peptides A proteomics right ventricular myocardial infarction[prognosis (bad)] acute inferior myocardial infarction Serra A et al. Am J Cardiol. 1991
natriuretic peptides A proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Niitsuma K et al. Jpn Circ J. 1991
natriuretic peptides A proteomics inducible myocardial ischemia[prognosis (bad)] acute myocardial infarction Morelli S et al. Ann Ital Med Int. 1991
natriuretic peptides A proteomics ventricular arrhythmia[prognosis (bad)] acute myocardial infarction Gorecki A et al. Pol Arch Med Wewn. 1991
natriuretic peptides A proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Fontana F et al. Eur Heart J. 1990
natriuretic peptides A proteomics left ventricular dysfunction[prognosis (bad)] acute myocardial infarction Fontana F et al. Eur Heart J. 1990
natriuretic peptides A proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Ngo L et al. Am Heart J. 1989
natriuretic peptides A proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Matsubara H et al. Am Heart J. 1987
natriuretic peptides A proteomics medium predictor cardiovascular death[prognosis (bad)] acute myocardial infarction Omland T et al. Am J Cardiol. 1995
natriuretic peptides A proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Bellone P et al. Int J Cardiol. 1993
natriuretic peptides A proteomics left ventricular dysfunction[prognosis (bad)] acute myocardial infarction Bellone P et al. Int J Cardiol. 1993
natriuretic peptides A proteomics cardiovascular death[prognosis (bad)] myocardial infarction Hall C et al. Circulation. 1994
natriuretic peptides A proteomics death[prognosis (bad)] myocardial infarction Hall C et al. Circulation. 1994
natriuretic peptides A proteomics left ventricular dysfunction[prognosis (bad)] acute myocardial infarction Kyriakidis M et al. Cardiology. 1993
natriuretic peptides A proteomics death[prognosis (bad)] acute myocardial infarction Omland T et al. Am J Cardiol. 1993
natriuretic peptides A proteomics exercise tolerance[other] acute myocardial infarction Omland T et al. Eur Heart J. 1993
natriuretic peptides A proteomics cardiovascular death[prognosis (bad)] acute myocardial infarction Nakamura M et al. Intern Med. 1993
natriuretic peptides A proteomics left ventricular ejection fraction[other] acute myocardial infarction Fontana F et al. Pain. 1995
natriuretic peptides A proteomics chest pain[other] acute myocardial infarction Fontana F et al. Pain. 1995
natriuretic peptides A proteomics reduced left ventricular ejection fraction[prognosis (bad)] acute myocardial infarction Omland T et al. Circulation. 1996
natriuretic peptides A proteomics old myocardial infarction[diagnosis] old myocardial infarction Marumoto K et al. Jpn Circ J. 1995
natriuretic peptides A proteomics adverse events[prognosis (bad)] acute myocardial infarction Darbar D et al. Am J Cardiol. 1996
natriuretic peptides A proteomics acute inferior myocardial infarction[diagnosis] acute inferior myocardial infarction Assali A et al. Clin Cardiol. 1997
natriuretic peptides A proteomics left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Nagaya N et al. Am Heart J. 1998
natriuretic peptides A proteomics left ventricular systolic dysfunction[prognosis (bad)] acute myocardial infarction Petersen CL et al. Cardiology. 1998
natriuretic peptides A proteomics left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Magga J et al. J Appl Physiol (1985). 2004
natriuretic peptides A proteomics exercise[other] old myocardial infarction Ikeda N et al. Regul Pept. 2007
natriuretic peptides A proteomics natriuretic peptides B[treatment (pharmacotherapy)] acute ST elevation myocardial infarction Hillock RJ et al. Heart. 2008
natriuretic peptides A proteomics medium predictor acute myocardial infarction[diagnosis] acute myocardial infarction Meune C et al. Am J Cardiol. 2012
natriuretic peptides A proteomics cardiovascular death[prognosis (bad)] acute myocardial infarction Berezin AE et al. Asian Cardiovasc Thorac Ann. 2013
natriuretic peptides A proteomics medium predictor cardiogenic shock[prognosis (bad)] ST elevation myocardial infarction Frydland M et al. Eur Heart J Acute Cardiovasc Care. 2020
natriuretic peptides A proteomics medium predictor acute type 2 myocardial infarction[diagnosis] acute type 2 myocardial infarction Horiuchi Y et al. Circulation. 2020
NM_006172.4:c.454T>C genomics myocardial infarction[diagnosis] myocardial infarction Gruchala M et al. Am Heart J. 2003
NM_006172.4:c.454T>C genomics myocardial infarction[diagnosis] myocardial infarction Cannone V et al. Hypertension. 2013
natriuretic peptides A proteomics good predictor death[prognosis (bad)] acute myocardial infarction Khan SQ et al. J Am Coll Cardiol. 2015
natriuretic peptides A proteomics medium predictor atrial fibrillation[prognosis (bad)] acute myocardial infarction Karolina I et al. Biomarkers. 2020
natriuretic peptides A proteomics adverse events[prognosis (bad)] acute non-ST elevation myocardial infarction Jernberg T et al. Am J Cardiol. 2002
natriuretic peptides A proteomics cardiovascular death[prognosis (bad)] acute myocardial infarction Retterstol L et al. Scand Cardiovasc J. 2001
natriuretic peptides A proteomics death[prognosis (bad)] acute myocardial infarction Retterstol L et al. Scand Cardiovasc J. 2001
natriuretic peptides A proteomics good predictor left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Hole T et al. Eur Heart J. 2004
natriuretic peptides A proteomics medium predictor death[prognosis (bad)] acute myocardial infarction Squire IB et al. Clin Sci (Lond). 2004
natriuretic peptides A proteomics poor predictor heart failure[prognosis (bad)] acute myocardial infarction Squire IB et al. Clin Sci (Lond). 2004
natriuretic peptides A proteomics medium predictor heart failure hospitalization[prognosis (bad)] acute myocardial infarction Squire IB et al. Clin Sci (Lond). 2004
natriuretic peptides A proteomics left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Yoshitomi Y et al. Int J Cardiol. 1998
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